Yes and No. There are multiple issues to check before ordering: You can definitely place two monitors of different sizes on a dual monitor bracket. The issue is usually vertical alignment. If you want both monitors centered in relation to one another, then make sure both monitors have VESA hole patterns that are either perfectly centered or happen to be off-center by a similar ratio. To understand how they will actually align, carefully place both monitors face down (stands removed) and find the vertical centers of those monitors and determine if the VESA mounts are centered on the back of both units. Some users will want to align monitors along the bottom. This is an even trickier proposition. It will be sheer luck if you find two different size monitors with VESA hole patterns on the back that actually meet your desire for bottom allignment. Again, lay the monitors face down to understand how they will align. Please also see the FAQ relating to differing monitor weights.